Stiripentol is often a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or lessened outcomes. CYP3A4 substrates may demand dosage adjustment.
Allergic reactions like rash, angioedema, anaphylaxis, and Stevens–Johnson syndrome may perhaps rarely be induced by an immunological response to modafinil or its metabolites.
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stiripentol will enhance the amount or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Intently. Take into account lessening the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.
Doses nearly four hundred mg/working day, provided as one dose, are nicely tolerated, but there's no constant evidence this dose confers more benefit beyond that with the two hundred mg/working day dose
Indicated to improve wakefulness in adults with excessive sleepiness related to change get the job done disorder (SWD)
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Stop using this medication and contact your physician immediately In case you have a pores and skin rash; itching; hives; hoarseness; problems breathing; problems swallowing; or any swelling within your palms, confront, or mouth when you are working with this medicine.
This medication might be useful for other uses; talk to your wellness care supplier or pharmacist In case you have concerns.
rifampin will decrease the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
An extensive literature critique based on Ovid Medline, EMBASE, the Cochrane and PSYCHInfo databases was conducted to determine printed reports on the influence of modafinil on fatigue and EDS affiliated with neurological Problems. Look for phrases made use of were detailed in dietary supplement S1.
Warfarin's significantly less powerful R-enantiomer is metabolized in part by CYP3A4 (and in addition CYP1A2 and CYP2C19). Watch INR additional usually if coadministered with inhibitors of those isoenzymes and alter warfarin dose if necessary.
Acceptable scientific tests haven't been read more carried out on the relationship of age to the results of modafinil in young children more youthful than seventeen yrs of age. Safety and efficacy have not been recognized.
Though correct scientific tests on the connection of age to the results of modafinil have not been done in the geriatric population, geriatric-certain troubles aren't expected to Restrict the usefulness of modafinil from the aged.